中国最大的导师数据查询系统
导师姓名:李成华
性别:
人气指数:5385
所属院校:宁波大学
所属院系:海洋学院
职称:研究员
导师类型:
招生专业:海洋生物学、生物化学与分子生物学、水产养殖、渔业资源、渔业发展
研究领域:

水产动物免疫生物学

研究领域:

水产动物免疫生物学 [收起]

通讯方式 :
电子邮件:lichenghua@nbu.edu.cn
个人简述 :

李成华,1978年9月生,博士,研究员,博士生导师,中国海洋与湖沼学会棘皮动物分会理事,浙江省动物学会理事,兼副秘书长。先后获得中国水产学会首届青年科技奖(2016年);浙江省151第二层次培养人员(2016年);国家优秀青年科学基金(2015年),宁波市领军和拔尖人才工程第一层次(2015年),浙江省杰出青年科学基金(2014年),浙江省高等学校中青年学科带头人(2013年)等人才工程资助。主持国家自然科学基金4项、浙江省杰出青年科学基金和浙江省科技厅国际合作项目等科研项目。目前主要从事海洋生物分子免疫学、病害防治和分子设计育种等方面的研究工作,在刺参免疫相关miRNA发掘和功能研究 以及病原微生物治病机制领域取得重要进展。以第一作者或通讯作者在“Frontiers in Immunology(IF3=6.062)”"Genetics(IF3=5.054)"、“Scientific Reports(IF3=5.022)”、"Journal of Hazardous Materials (IF3=5.143)"、“Developmental & Comparative Immunology(IF3=3.218)”等期刊发表SCI论文80余篇,个人H指数26;获得授权发明专利4项;指导研究生获得国家奖学金9人次(4年)。

科研工作 :

2010年以前:

(1)Li C., Song L*., Zhao J., Zou H., Su J., Zhang H. Genomic organization, nucleotide sequence analysis of the core histone genes cluster in Chlamys farreri and molecular evolution assessment of the H2A and H2B. DNA Sequence. 2006 17(6): 440-451.(IF=0.569)

(2)Li C., Song L*., Zhao J., Zhu L., Zou H., Zhang H., Wang H., Cai Z. The preliminary study on a potential antibacterial peptide derived from histone H2A in hemocytes of scallop Chlamys farreri. Fish Shellfish Immunol. 2007, 22 (6): 663-672. (IF=3.160)

(3)Li C., Zhao J., Song L*., Mu C., Zhang H., Gai Y., Qiu L., Yu Y., Ni D., Xing K. Molecular cloning, characterization, expression and functional analysis of an anti-lipopolysaccharide factor from Chinese mitten crab Eriocheir sinensis. Dev Comp Immunol. 2008, 32(7):784-794.(IF=2.833)

(4)Li C., Ni D., Song L*., Zhao J., Zhang H. Li L. Molecular cloning and characterization of a catalase from Zhikong scallop Chlamys farreri. Fish Shellfish Immunol. 2008, 24 (1): 27-34.(IF=3.160)

(5)Li C*., Zhao J., Song L*. A review of advances in research on marine molluscan antimicrobial peptides and their potential application in aquaculture. Molluscan Res. 2009, 29(1):17-26.(Invited Review). (共同通讯作者)(IF=0.583)

2010年:

(1)Zhao J., Li C*., Chen A., Li L., Su X., Li T. Molecular characterization of a novel big defensin from clam Venerupis philippinarum. PLoS One. 2010, 5(10):e13480. (通讯作者) (IF=4.411)

(2)Li C., Wang L., Ning X., Chen A., Zhang L., Qin S., Wu H., Zhao J*. Identification two small heat shock proteins with different response profile to environmental stresses in Venerupis philippinarum. Cell Stress Chaperon. 2010, 15(6): 897-904. (IF=3.162)

(3)Zhao J., Qiu L., Ning X., Chen A., Wu H., Li C*. Cloning and characterization of an Invertebrate type lysozyme from Venerupis philippinarum. Comp Biochem Phys B 2010, 156: 56-60. (通讯作者) (IF=1.989)

(4)Li C*., Zhang H., Li L., Song L*. Identification of a cathepsin D potentially involved in H2A cleavage from scallop Chlamys farreri. Mol Biol Rep. 2010, 37(3): 1451-1460. (共同通讯作者)(IF=1.875)

(5) Li C., Qiu L., Ning X., Chen A., Qin S., Wu H., Zhao J*. The first molluscan TCTP in Venerupis philippinarum: molecular cloning and expression analysis. Fish Shellfish Immunol. 2010, 29(9): 530-533.(IF=3.044)

(6)Li C., Sun H., Chen A., Ning X., Wu H., Qin S., Xue Q., Zhao J*. Identification and characterization of an intracellular Cu, Zn-superoxide dismutase (icCuZnSOD) gene from clam Venerupis philippinarum. Fish Shellfish Immunol. 2010, 28: 499-503. (IF=3.044)

2011年:

(1)Jin C., Li C*., Su X., Li T. Identification and characterization of a Tegillarca granosa ferritin regulated by iron ion exposure and thermal stress. Dev Comp Immunol. 2011, 35:745-751. (通讯作者) (IF=3.268)

(2)Li C*., He J., Su X., Li T. A manganese superoxide dismutases in blood clam Tegillarca granosa: molecular cloning, tissues distribution and expression analysis. Comp Biochem Phys B 2011, 159:64-70. (通讯作者)(IF=1.923)

(3)Li C., Li H., Su X., Li T*. Identification and characterization of a clam ferritin from Sinonovacula constricta. Fish Shellfish Immunol. 2011, 30:1147-1151 (IF=3.322)

(4)Li C., Li L., Liu F., Ning X., Chen A., Zhang L., Wu H., Zhao J*. Alternation of Venerupis philippinarum Hsp40 gene expression in response to pathogen challenge and heavy metal exposure. Fish Shellfish Immunol. 2011, 30(1):447-450.(IF=3.322)

(5)Zhang L., Zhao J., Li C*., Su X., Chen A., Li T., Qin S. Cloning and characterization of allograft inflammatory factor-1 (AIF-1) from manila clam Venerupis philippinarum. Fish Shellfish Immunol. 2011, 30(1): 148-153. (通讯作者). (IF=3.322)

(6)Li C*., Yu S., Zhao J., Su X., Li T. Cloning and characterization of a sialic acid binding lectins (SABL) from Manila clam Venerupis philippinarum. Fish Shellfish Immunol. 2011, 30:1202-1206. (通讯作者)(IF=3.322)

(7)李成华,崔静,李晔,周君,苏秀榕,李太武*。南移养殖仿刺参(Stichopus japonicus Selenka)铁蛋白基因的克隆机表达特征分析。海洋与湖沼。2011,42(7):567-572.

2012年:

(1)Li C., Li Z., Li Y., Zhou J., Zhang C., Su X*., Li T. A ferritin from Dendrorhynchus zhejiangensis with heavy metals detoxification activity. Plos ONE. 2012, 7(12):e51428.(IF=3.73)

(2)Li C*., Su X*., Li Y., Li T., Sun C., Zhou T., Liu H. Two classes of glutathione S-transferase genes with different response profiles to bacterial challenge in Venerupis philippinarum. Fish Shellfish Immunol. 2012, 32(1):219-222. (共同通讯作者)(IF=2.964)

(3)Li C*., Feng W., Qiu L., Xia C., Su X*., Jin C., Zou T., Zeng Y., Li T. Characterization of skin ulceration syndrome associated microRNAs in sea cucumber Apostichopus japonicus by deep sequencing. Fish Shellfish Immunol. 2012,33(2):436-441. (共同通讯作者) (IF=2.964)

(4)Li C., Ying Q., Su X*., Li T. Development and application of reverse transcription loop-mediated isothermal amplification for detecting live Shewanella putrefaciens in preserved fish sample. J Food Sci 2012, 77(4):M226-M230(IF=1.775)

(5)Li C*., Su X*., Wang M., Li Y., Li Y., Zhou J., Li T. Alteration of Phascolosoma esculenta heat shock protein 90 expression under heavy metal exposure and thermal stress. Genet Mol Res 2012,11 (3):2641-2651. (共同通讯作者)(IF=0.994)

2013年:

(1) Zhang P., Li C*., Zhu L., Su X., Li Y., Jin C., Li T. De novo assembly of the sea cucumber Apostichopus japonicus hemocytes transcriptome to identify miRNA targets associated with skin ulceration syndrome. PLoS One. 2013, 8(9):e73506. (通讯作者)(IF=3.534)

(2)Zhang P., Lu Y., Li C*., Su X., Wang Z., Jin C., Li Y., Li T. Identification of differential expressed proteins and characterization their mRNA expression in thermally stressed Apostichopus japonicus. Comp. Biochem. Physiol. D. 2013, 8(3):194-200. (通讯作者)(IF=2.823)

(3)Liu Y., Li C*., Su X*., Wang M., Li Y., Li Y., Li T. Cloning and characterization of hemerythrin gene from Sipuncula Phascolosoma esculenta. Genes Genom 2013, 35:95-100. (共同通讯作者) (IF=0.565)

(4)Lu Y., Zhang P., Li C*., Su X., Jin C., Li Y., Li T. Characterisation of immune-related gene expression in clam (Venerupis philippinarum) under exposure to di(2-ethylhexyl) phthalate. Fish Shellfish Immunol. 2013, 34(1):142-146. (通讯作者)(IF=3.034)

(5)Zhang A., Lu Y., Li C*., Zhang P., Su X., Li Y., Wang C., Li T. A small heat shock protein (sHSP) from Sinonovacula constricta against heavy metals stresses. Fish Shellfish Immunol. 2013, 34(6):1605-1610. (通讯作者)(IF=3.034)

(6)Lu Y., Zhang A., Li C*., Zhang P., Su X., Li Y., Mu C., Li T. The link between selenium binding protein from Sinonovacula constricta and environmental pollutions exposure. Fish Shellfish Immunol. 2013, 35(2):271-277. (通讯作者)(IF=3.034)

(7)Lu Y., Li C*., Zhang P., Shao Y., Su X., Li Y., Li T. Two adaptor molecules of MyD88 and TRAF6 in Apostichopus japonicus Toll signaling cascade: molecular cloning and expression analysis. Dev Comp Immunol. 2013, 41(4):498-504. (通讯作者)(IF=3.705)

(8)Zhu L., Li C*., Su X., Guo C., Wang Z., Jin C., Li Y., Li T. Identification and assessment of differentially expressed genes involved in growth regulation in Apostichopus japonicus. Genet Mol Res 2013,12 (3):3028-3037. (通讯作者)(IF=0.85)

(9) 张鹏,李成华*,李晔,苏秀榕,金春华,李太武. 刺参(Apostichopus japonicus)腐皮综合症发生相关蛋白的分离与鉴定. 海洋与湖沼。2013, 44(3):741-746. (通讯作者)

(10) Shao Y., Li C*., Ou C*., Zhang P., Lu Y., Su X., Li Y. Li T. Divergent metabolic responses of Apostichopus japonicus suffered from skin ulceration syndrome and pathogen challenge. J Agric Food Chem. 2013, 61(45):10766-10771. (共同通讯作者) (IF=3.107)

(11)Lu Y., Li C*., Zhang P., Wang D., Su X., Jin C., Li Y., Li T. Characterization of two negative regulators of the Toll-like receptor pathway in Apostichopus japonicus: Inhibitor of NF-κB and Toll-interacting protein. Fish Shellfish Immunol. 2013, 35(5):1663-1669. (通讯作者) (IF=3.034)

2014年

(1) 朱琳,郭春阳,王振,李成华*.基于抑制消减杂交识别白化刺参和青刺

参差异表达基因。宁大学报理工版。2014, 27(1):8-12. (通讯作者)

(2)Zhang P., Li C*., Li Y*., Zhang P., Saho Y., Jin C., Li T. Proteomic identification of differentially expressed proteins in sea cucumber Apostichopus japonicus coelomocytes after Vibrio splendidus infection. Dev Comp Immunol. 2014, 44(2):370-377. (共同通讯作者)(IF=2.815)

(3) Zhang P., Li C*., Shao Y., Chen X., Li Y., Su X., Li T. Identification and characterization of miR-92a and its targets modulating Vibrio splendidus challenged Apostichopus japonicus. Fish Shellfish Immunol. 2014, 38(2):383-385. (通讯作者) (IF=2.674)

(4) Zhang P., Li C*., Zhang P., Jin C., Pan D., Bao Y. iTRAQ-based proteomics reveals novel members involved in pathogen challenge in sea cucumber Apostichopus japonicus. PLoS One. 2014, 9(6):e100492. (通讯作者)(IF=3.234)

(5) Li C*., Chen X., Zhang P., Lu Y., Zhang R. Di-(2-ethylhexyl) phthalate mediates glycolysis and the TCA cycle in clam Venerupis philippinarum. Invert Surviv J. 2014, 11:174-181. (通讯作者)(IF=0.929)

(6) Chen X., Zhang R., Li C*., Bao Y*. Mercury exposure modulates antioxidant enzymes in gill tissue and hemocytes of Venerupis philippinarum. Invert Surviv J. 2014, 11:298-308. (共同通讯作者)(IF=0.906)

2015年:

(1) Zhang X., Zhang P., Li C*., Li Y., Jin C., Zhang W. Characterization of two regulators of the TNF-α signa ling pathway in Apostichopus japonicus: LPS- induced TNF-α factor and baculoviral inhibitor ofapoptosisrepeat-containing 2. Dev Comp Immunol. 2015, 48(1):138-142. (通讯作者)(IF=3.62)

(2)Shao Y., Li C*., Chen X., Zhang P., Li Ye., Li T., Jiang J. Metabolomic responses of sea cucumber Apostichopus japonicus to thermal stresses. Aquaculture. 2015, 435:390-397. (通讯作者)(IF=1.893)

(3)Wang H., Zhang W*., Li C*., Lv Z., Jin C. Identification and characterization of a novel Foxo transcription factors in Apostichopus japonicus. Fish Shellfish Immunol. 2015, 44(1):164-171.(共同通讯作者) (IF=3.025)

(4)张秀梅,李成华*.脂多糖诱导的肿瘤坏死因子(LITAF)生物学功能研究进展。中国细胞生物学学报。2015, 37(4):553-559. (通讯作者)

(5)Lv Z., Li C*., Zhang P., Wang Z., Zhang W., Jin C. miR-200 modulates coelomocytes antibacterial activities and LPS priming via targeting Tollip in Apostichopus japonicas. Fish Shellfish Immunol. 2015, 45(2):431-436.(通讯作者) (IF=3.025)

(6)Lu M., Zhang P., Li C*., Zhang W., Jin C., Han Q. MiR-31 modulates coelomocytes ROS production via targeting p105 in Vibrio splendidus challenged sea cucumber Apostichopus japonicus in vitro and in vivo. Fish Shellfish Immunol. 2015, 45(2):293-299.(通讯作者) (IF=3.025)

(7)Shao Y., Li C*., Che Z., Zhang P., Zhang W., Duan X., Li Y. Cloning and Characterization of two lipopolysaccharide-binding protein/ bactericidal permeability-increasing protein (LBP/BPI) genes from the sea cucumber Apostichopus japonicus with diversified function in modulating ROS production. Dev Comp Immunol. 2015, 52(1):88-97. (通讯作者)(IF=3.62)

(8)Wang H., Shao Y., Li C*., Zhang W., Lv Z., Jin C*. Molecular characterization of two novel molecular chaperones in bacterial-challenged Apostichopus japonicus. Gene. 2015, 570(1):141-147 (共同通讯作者)(IF=2.319)

(9)Lu M., Zhang P., Li C*., Lv Z., Zhang W., Jin C. miRNA-133 augments coelomocyte phagocytosis in bacteria-challenged Apostichopus japonicus via targeting the TLR component of IRAK-1 in vitro and in vivo. Sci. Rep. 2015, 5:12608. (通讯作者)(IF=5.228)

(10)Shao Y., Li C*., Zhang W., Duan X., Li Y., Han Q., Jin C. Three members in JAK/STAT signal pathway from the sea cucumber Apostichopus japonicus: Molecular cloning, characterization and function analysis. Fish Shellfish Immunol. 2015, 46(2):523-536.(通讯作者) (IF=3.025)

(11)陈晓聪,张冉,李成华*,包永波. 菲律宾蛤仔(Venerupis philippinarum)对重金属Hg2+的富集及相关生物标记物的识别. 海洋与湖沼. 2015, 46(4): 928-935.

(12)Zhang P., Li C*., Zhang R., Zhang W., Jin C., Wang L., Song L. The roles of two miRNAs in regulating the immune response of sea cucumber. Genetics. 2015, 201(4): 1397-1410(IF=4.644

2016年:

(1)Lv Z., Li C., Zhang W., Jin C., Shao Y., Duan X., Han Q. Nemo like kinase negatively regulates NF-κB activation and coelomocytes apoptosis in Apostichopus japonicus. Dev Comp Immunol. 2016, 54(1):109-115. (通讯作者)(IF=3.218)

(2)Zhang W., Liang W., Li C*. Inhibition of marine Vbirio sp. by pyoverdine from Pseudomonas seruginosa PA1. J Hazard Mater. 2016, 302: 217-224. (IF=6.065)

(3)Zhang W., Li C*.Exploiting quorum sensing interfering strategies in gram-negative bacteria for the enhancement of environmental applications.Front. Microbiol.2015, 6:1535.(IF=4.076)

(4)Zhang P., Li C*. Advances on computational methods for identifying the targets of microRNAs: A review. Curr. Bioinform. 2016,11(3):304--309. (通讯作者)(IF=0.600)

(5)Sun X., Lv Z., Li C*., Lu M., Zhang P., Zhang W. Identification and characterization of miR-31 potential targets by RNA-seq. Fish Shellfish Immunol. 2016, 51(1):26-32 (共同通讯作者) (IF=3.148)

(6)Wang H., Li C*., Wang Z., Shao Y., Lv Z., Zhang W. p44/42MAPK and p90RSK modulate thermal stressed physiology response in Apostichopus japonicus. Comp. Biochem. Physiol. B. 2016, 196-197(1):57-66. (通讯作者)(IF=1.757)

(7)Shao Y., Li C*., Zhang W., Wang Z., Lv Z. The first description of complete invertebrate arginine metabolism pathways implies dose-dependent pathogen regulation in Apostichopus japonicus. Sci. Rep. 2016, 6:23783. (通讯作者)(IF=4.259)

(8)Wang Z., Shao Y., Li C*., Lv Z., Wang H., Zhang W., Zhao X. A β-Integrin from sea cucumber Apostichopus japonicus exhibits LPS binding activity and negatively regulates coelomocyte apoptosis. Fish Shellfish Immunol. 2016, 52(1):103-110 (通讯作者) (IF=3.148)

(9)Shao Y., Wang Z., Lv Z., Li C*., Zhang W., Li Y., Duan X. NF-κB/Rel, not STAT5, regulates nitric oxide synthase transcription in Apostichopus japonicus. Dev Comp Immunol. 2016, 61(1):42-47. (通讯作者)(IF=3.218)

(10)Fan W., Ye Y., Chen Z., Shao Y., Xie X., Zhang W., Liu H*., Li C*. Metabolic product response profiles of Cherax quadricarinatus towards white spot syndrome virus infection. Dev Comp Immunol. 2016, 61(1):236-241. (共同通讯作者)(IF=3.218)

(11)Lv Z., Li C*., Shao Y., Zhang W., Wang Z., Wang H. Programmed cell death 4 in bacterially-challenged Apostichopus japonicus: molecular cloning, expression analysis and functional characterization. Mol Immunol. 2016, 75(1):84-91. (通讯作者)(IF=3.236)

(12)Shao Y., Li C*., Zhang W., Duan X., Li Y., Jin C., Xiong J., Qiu Q. Molecular cloning and characterization of four Caspases members in Apostichopus japonicus. Fish Shellfish Immunol. 2016, 55(1):203-211. (通讯作者)(IF=3.148)

(13)Liang W., Zhang C., Liu N., Zhang W*., Han Q., Li C*. Cloning and characterization of Vshppd, a gene inducing haemolysis and immune response of Apostichopus japonicus. Aquaculture. 2016, 464(1):246--252 (共同通讯作者)(IF=2.570)

(14)Shao Y., Li C*., Zhang W., Duan X., Li Y., Qiu Q., Jin C. Cloning and comparative analysis the proximal promoter activities of arginase and agmatinase genes in Apostichopus japonicus. Dev Comp Immunol. 2016, 65(1):299-308. (通讯作者)(IF=3.218)

(15)Li C*., Zhao M., Zhang C., Zhang W., Zhao X., Duan X., Xu W*. miR210 modulates respiratory burst in Apostichopus japonicus coelomocytes via targeting Toll-like receptor. Dev Comp Immunol. 2016, 65(1):377-381. (第一作者,共同通讯作者)(IF=3.218)

(16)Wang Z., Shao Y., Li C*., Zhang W., Duan X., Zhao X., Qiu Q., Jin C. RNA-seq analysis revealed ROS-mediated related genes involved in cadmium detoxification in the razor clam Sinonovacula constricta. Fish Shellfish Immunol. 2016, 57(1):350-361 (通讯作者)(IF=3.148)

(17)Liang W., Zhang S., Zhang W*., Li C*., Han Q. Characterization of functional furVs as a biomarker for detection of aquatic pathogen Vibrio splendidus. Journal of the World Aquaculture Society. 2016, 47(4):577--586 (共同通讯作者)(IF=1.015)

(18)Zhang C., Liang W., Zhang W*., Li C*. Characterization of a metalloprotease involved in Vibrio splendidus infection in the sea cucumber, Apostichopus japonicus. Microb. Pathogenesis. 2016, 101:96--103 (共同通讯作者)(IF=2.009)

(19)Bao Y., Liu X., Zhang W., Cao J., Li W., Li C*., Lin Z*. Identification of a regulation network in response to cadmium toxicity using blood clam Tegillarca granosa as model. Sci. Rep. 2016, 6:35704. (共同通讯作者)(IF=4.259)

(20)Zhao M., Meng C., Xie X., Li C*., Liu H*. Characterization of microRNAs by deep sequencing in red claw crayfish Cherax quadricarinatus haematopoietic tissue cells after white spot syndrome virus infection. Fish Shellfish Immunol. 2016, 59:469-483. (共同通讯作者)(IF=3.148)

(21)车钟杰,邵铱娜,李成华*,张卫卫。刺参杀菌通透性增强蛋白N末端结构域重组蛋白的制备及功能分析。宁大学报理工版。2016, 29(3):34-38. (通讯作者)

2017年:

(1)Lv M., Chen H., Shao Y., Li C*., Xu W., Zhang W., Zhao X., Duan X. miR-137 modulates coelomocyte apoptosis by targeting 14-3-3ζ in the sea cucumber Apostichopus japonicus. Dev Comp Immunol. 2017, 67:86-96. (通讯作者)(IF=3.218)

(2)Chen H., Lv M., Lv Z., Li C*., Xu W., Zhang W., Zhao X., Duan X., Jin C. Molecular cloning and functional characterization of cathepsin B from the sea cucumber Apostichopus japonicus. Fish Shellfish Immunol. 2017, 60(1):447-457. (通讯作者)(IF=3.148)

(3)Zhang S., Liu N., Liang W., Han Q., Zhang W*., Li C*. Quorum sensing-disrupting coumarin suppressing virulence phenotypes in Vibrio splendidus. Appl Microbiol Biotechnol. 2017, 101(8):3371--3378 (共同通讯作者)(IF=3.420)

(4)Liu N., Zhang S., Zhang W*., Li C*. Vibrio sp. 33 a potential bacterial antagonist of Vibrio splendidus pathogenic to sea cucumber (Apostichopus japonicus). Aquaculture 2017, 470:68--73 (共同通讯作者)(IF=2.570)

(5)Shao Y., Lv Z., Li C*., Zhang W., Duan X., Qiu Q., Jin C., Zhao X. Molecular cloning and functional characterization of theta class glutathione S-transferase from Apostichopus japonicas. Fish Shellfish Immunol. 2017, 63:31-39. (通讯作者)(IF=3.148)

(6)Shao Y., Li C*., Xu W., Zhang P., Zhang W., Zhao X. miR-31 links lipid metabolism and cell apoptosis in bacteria-challenged Apostichopus japonicus via targeting CTRP9. Front. Immunol. 2017, 8: 263 (通讯作者)(IF=6.429)

(7)Zhang Z., Lv M., Shao Y., Qiong Q., Zhang W., Duan X., Li Y., Li C*. Microsomal glutathione transferase 1 attenuated ROS-induced lipid peroxidation in Apostichopus japonicus. Dev Comp Immunol. 2017, 73:79-87. (共同通讯作者)(IF=3.218)

(8)Chen H., Lv M., Lv Z., Li C*., Zhang W., Zhao X., Duan X., Jin C., .Xiong J., Xu F., Li Y. Divergent roles of three cytochrome c in CTSB-modulating coelomocyte apoptosis in Apostichopus japonicus. Dev Comp Immunol. 2017, 76:65-76. (通讯作者)(IF=3.218)

(9)Zhao X., Duan X., Wang Z., Zhang W., Li Y., Jin C.. Xiong J., Li C*. Comparative transcriptome analysis of Sinonovacula constricta in gills and hepatopancreas in response to Vibrio parahaemolyticus infection. Fish Shellfish Immunol. 2017, 67:523-535. (通讯作者)(IF=3.148)

(10)Lv Z., Wei Z., Zhang Z., Li C*., Shao Y., Zhang W., Zhao X., Li Y., Duan X., Xiong J. Characterization of NLRP3-like gene from Apostichopus japonicus provides new evidence on inflammation response in invertebrates. Fish Shellfish Immunol. 2017, 68(1):114-123. (通讯作者)(IF=3.148)

(11)Lv Z., Zhang Z., Wei Z., Li C*., Shao Y., Zhang W., Zhao X., Xiong J. HMGB3 modulates ROS production via activating TLR cascade in Apostichopus japonicus. Dev Comp Immunol. 2017, 77:128-137. (通讯作者)(IF=3.218)

(12)Shao Y., Lv Z., Chen H., Lv M., Li C*., Zhang W., Li Y., Zhao X., Bao Y*. A novel TNFAIP8 gene mediates L-arginine metabolism in Apostichopus japonicus. Fish Shellfish Immunol. 2017, 69(1):26-34. (共同通讯作者)(IF=3.148)

(13)Lv M., Chen H., Shao Y., Li C*., Zhang W., Zhao X., Jin C., Xiong J. miR-92a regulates coelomocytes apoptosis in sea cucumber Apostichopus japonicus via targeting Aj14-3-3ζ in vivo. Fish Shellfish Immunol. 2017, In press. (通讯作者)(IF=3.148)

(14)Zhang Z., Lv Z., Wei Z., Li C*., Shao Y., Zhang W., Zhao X., Xiong J. Microsomal glutathione transferase 2 modulates LTC4 synthesis and ROS production in Apostichopus japonicus. Mol Immunol. 2017, In press. (通讯作者)(IF=3.236)

(15)Zhang S., Zhang W., Liu N., Song T., Liu H., Zhao X., Xu W., Li C*. Indole reduces the expression of virulence related genes in Vibrio splendidus pathogenic to sea cucumber Apostichopus japonicas. Microb. Pathogenesis. 2017, 111:168-173 (通讯作者)(IF=2.009)

中国海洋与湖沼学会棘皮动物分会理事,浙江省动物学会理事,兼副秘书长。

(1) 水产动物免疫生物学,国家自然科学基金/优秀青年科学基金,31522059,2016.1---2018.12,150.0万元(主持)

(2) 缢蛏高产、抗逆新品种培育,报浙江省农业新品种选育重大科技专项,2016C02055-9,2016.1---2020.12,450.0万元,子课题负责人

(3) miR-31靶向调控刺参腐皮综合症发生的分子机制研究,国家自然科学基金/面上项目,41576139,2016.1---2019.12,88.8万元(主持)

(4) 缢蛏快速生长品系的选育和遗传学基础解析,宁波市市科技局/农业与社会发展攻关项目,215C10009,2015.3---2017.3,20.0万元(主持)

(5) 基于可逆蛋白磷酸化层面上的南移仿刺参应答高温胁迫机制的研究,国家自然科学基金/面上项目,41276120,2013.1---2016.12,78.0万元(主持)

(6) 刺参腐皮综合症发生相关microRNAs的发掘和表达研究,国家自然科学基金/青年科学基金,31101919,2012.1---2014.12,23.0万元(主持)

(7) 基于miRNA调控网络的刺参腐皮综合症发生机制解析,浙江省杰出青年科学基金,LR14C190001,2014.1---2016.12,34.0万元(主持)

(8) 基于高通量转录组测序的刺参腐皮综合症发生及其早期预警产品的研发,宁波市科技局/农业与社会发展攻关项目,2013C10013,2013.4---2015.3,15.0万元(主持)

(9) 南移刺参生态苗种繁育技术开发与示范,科技部科技部星火计划,2011.1---2012.12(主持)

(10)基于miRNA调控视角的刺参腐皮综合症发生的分子机制,浙江省教育厅中青年学科带头人学术攀登项目,2013.6---2015.12,5.0万元(主持)

(11)基于抑制性消减文库基础上的南移养殖刺参良种选育研究,浙江省海水养殖创新团队自主设计项目,2011.4---2014.3,7.0万元(主持)

(12)基于菲律宾蛤仔响应模式的DEHP污染物快速预警系统的研究,浙江省科技厅国际合作项目,2013.1---2015.12,20.0万元(主持)

(13)基于南移养殖刺参的良种选育与分子标记研究,宁波市自然科学基金,2011.1---2012.12,4.0万元(主持)

(14)重要海域致病性细菌基因芯片检测技术研究开发与示范,国家海洋局公益性行业专项,2011.1---2014.12,902.0万元(第二负责人)

(1) 李成华、李太武、李晔、苏秀榕、金春华、郑忠明、张春丹。南移刺参浑水养殖、加工和良种筛选关键技术的集成与应用,浙江省高等学校科研成果奖一等奖,第一完成人。

(2) 基于星虫和海蜇功能基因和功能蛋白的探究,国家海洋局海洋创新奖二等奖,第三完成人。

(3) 李成华、张蕾、赵建民、苏秀榕、李太武。菲律宾哈仔免疫基因的克隆与表达研究,2012年宁波大学青年学术创新奖(自然科学类)二等奖,第一完成人。

(4) 李成华、李慧、苏秀榕、李太武。缢蛏铁蛋白基因的克隆与表达研究,2012年浙江省自然科学学术奖三等奖,第一完成人。

(5) 李成华,张鹏娟、金春华,李太武,李晔,欧昌荣,张卫卫。用于刺参腐皮综合症早期诊断的分子标记物及其扩增产物和

应用。发明专利,专利号:ZL201410209458.8.

(6) 李成华 陈晓聪 金春华 李晔 张卫卫 韩庆喜。用于检测环境污染物DEHP的基因芯片及其制备方法和应用。发明专利,专利号:ZL201510284160.8. 2017.5.3

(7) 李成华 邵铱娜 张卫卫 车钟杰 张鹏娟 金春华 李晔 欧昌荣。刺参BPI基因、编码蛋白及其克隆方法和重组刺参BPI基因工程菌构建方法。发明专利,专利号:ZL201510136343.5 2017.6.27

(8) 李成华,秦松,陈爱琴,夏传海。一种强抗氧化活性的组合物及其应用。发明专利,专利号:ZL200910255706.1

(9) 李成华,金春华,张安国、郑岳夫、郑忠明、李太武、谢碧博。刺参南移吊笼养殖技术规范。 宁波市地方标准规范,DB 3302/T 152—2014

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